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Figure 2 | Cell Communication and Signaling

Figure 2

From: Succinate causes pathological cardiomyocyte hypertrophy through GPR91 activation

Figure 2

Sustained levels of serum succinate cause increase in blood pressure on day 4 of treatment, but do not affect heart rate throughout the experiment. Medium Arterial Pressure levels in control animals and succinate treated animals, with or without IV injection of losartan on the 3rd day (A), 4th day (B) and 5th day of treatment (C) (**p < 0.01, ***p < 0.001). D. Mean heart rate of control and succinate treated rats during the experiment. E. Serum succinate concentration measured on the last day of experiment.

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