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Figure 6 | Cell Communication and Signaling

Figure 6

From: The T-box transcription factor Brachyury promotes renal interstitial fibrosis by repressing E-cadherin expression

Figure 6

Brachyury is induced specifically in the degenerated tubular epithelia of the fibrotic kidney. (A) Immunohistochemical analysis shows inverse correlation of TGF-β1, Brachyury, Snail, Slug and E-cadherin in IgA Nephropathy and normal renal biopsy samples from patients. TGF-β1,Brachyury, Slug, Snail-negative/E-cadherin preserved case. TGF-β1,Brachyury,Slug, Snail-positve/E-cadherin reduced case. Original magnification × 400. (B) Correlation plots of tubulointerstitial expression of active Brachyury and tubulointerstitial fibrosis. Scatter plot with fitted value intervals for percent tubular expression of Brachyury and tubulointerstitial fibrosis.

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Cell Communication and Signaling

ISSN: 1478-811X