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Figure 6 | Cell Communication and Signaling

Figure 6

From: Activation of C6 glioblastoma cell ceruloplasmin expression by neighboring human brain endothelia-derived interleukins in an in vitro blood-brain barrier model system

Figure 6

Model of BMVEC-induced sequestration of iron from the blood to the brain interstitium under stimuli from bacterial endotoxin. (A) The bacterial endotoxin Lipopolysaccharide (LPS) interacts with the apical surface of BMVEC resulting in enhanced gene expression of IL-6 (B). (C) IL-6 secreted from the basolateral surface of BMVEC binds with its receptor on the cell surface of neighboring astrocytes triggering a signaling cascade leading to increased sCp gene expression. (D) This increase in sCp transcript relates to an increase in sCp protein secreted from astrocytes resulting in increased iron efflux from the basolateral surface of BMVEC.

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Cell Communication and Signaling

ISSN: 1478-811X