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Table 4 Results of the fitting process for the integrative model

From: Agent-based modeling of autophagy reveals emergent regulatory behavior of spatio-temporal autophagy dynamics

 

Relative creation rate phagophores

Relative creation rate lysosomes

Relative degradation rate autolysosomes

Relative lysosomal positioning

Resulting difference free nutrients

FM

1

1

1

0%

0

FM?+?BAF

1.61

1.2

0.1

+ 2.2%

4.4

ND

4.86

2.98

12.04

+ 5.25%

10.5

ND?+?BAF

6.63

3.6

2.61

+ 8.55%

17.1

  1. The relative change of the creation rate of phagophores and lysosomes, the degradation rate of autolysosomes and of lysosomal positioning for FM with BAF and ND with and without BAF which obtain the best fitness values are shown in comparison to FM conditions.
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Cell Communication and Signaling

ISSN: 1478-811X