Skip to main content

Advertisement

Figure 4 | Cell Communication and Signaling

Figure 4

From: Agent-based modeling of autophagy reveals emergent regulatory behavior of spatio-temporal autophagy dynamics

Figure 4

Core model simulation of autophagic flux dynamics. The core model was simulated for 100 runs under indicated conditions for 3 hours. For each agent the plotted shaded area corresponds to the 25 and 75 quantile of data. A Time course of vesicle count under FM conditions. B Time course of the vesicle size under FM conditions. C Time course of vesicle count under FM conditions with the addition of BAF. D Time course of the vesicle size under FM conditions with the addition of BAF. E-F Comparison of simulation results to experimentally determined values. E (Right side) Simulated mean vesicle count at the 3 hour time point, with and without the addition of BAF. (Left side) Experimentally measured results (from Figure 3). F (Right side) Simulated mean vesicle size at the 3 hour time point, with and without the addition of BAF. (Left side) Experimentally measured results (from Figure 3). The blue shaded box indicates conditions in the presence of BAF.

Back to article page