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Figure 7 | Cell Communication and Signaling

Figure 7

From: NR5A1 prevents centriole splitting by inhibiting centrosomal DNA-PK activation and β-catenin accumulation

Figure 7

Proposed model of SF-1 action in the centrosome. In the centrosome, SF-1 interacts with Ku and cyclin A to prevent the DNA-PK/Akt signaling cascade. In the absence of SF-1, DNA-PKcs and cyclin A are recruited to the centrosome, leading to the activation of DNA-PK and Akt. This signaling cascade leads to GSK3β inactivation and β-catenin accumulation in the centrosome, therefore inducing centriole splitting. On the other hand, accumulation of cyclin A leads to CDK2 activation, thus facilitating centriole amplification. Solid arrows: proven activation step. Dotted arrows: indirect activation, perpendicular lines: inhibitory step.

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Cell Communication and Signaling

ISSN: 1478-811X