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Figure 6 | Cell Communication and Signaling

Figure 6

From: NR5A1 prevents centriole splitting by inhibiting centrosomal DNA-PK activation and β-catenin accumulation

Figure 6

SF-1 depletion activates DNA-PK signaling and causes accumulation of β-catenin and GSK3β in the centrosome. (A, C) Centrosomal or (B) whole cell extracts (WCE) of shluc or shsf1#3 lentivirus infected Y1 cells in the presence or absence of DNA-PK inhibitor, vanillin, were analyzed by immunoblotting with antibodies against β-catenin (β-cat), phosphorylated GSK3β (pGSK3β), GSK3β, SF-1, γ-tubulin (γ-tub), phsophorylated Akt (pAkt), Actin and Hsc70.

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Cell Communication and Signaling

ISSN: 1478-811X