Figure 3

Structure of MRCKβ in complex with ADP and BDP5290. Stereo views of the MRCKβ active site in complex with ADP (A) or BDP5290 (B). The ligands are shown in cyan and purple, respectively. Protein residues are coloured grey and labelled. Mg²⁺ ions are shown as light green spheres, selected water molecules are indicated by red spheres. Dotted black lines represent potential hydrogen bonding interactions. |F_o|-|F_c|, φ_c electron density maps calculated prior to the initial inclusion of the ligands in their respective models are shown contoured at 2.6σ. This figure was created using PyMOL.