Figure 7

Catalytic-independent functions of PDK1. (A) PDK1 induces activation of the Ral small G protein by binding to and relieving its GEF, Ral-GDS from the autoinhibitory conformation. (B) PDK1 mediates NFB activation in T-cells by serving as a scaffold that brings CARMA1-BCL10-MALT1complex proximal to the PKCq-bound IKK complex, thus allowing ubiquitination of NEMO (IKKγ). This leads to activation of IKKs, phosphorylation and subsequent degradation of the NFκB inhibitor IκB and release of active NFκB into the nucleus.