Figure 6
From: The secret life of kinases: functions beyond catalysis
PI3K signaling independent of catalytic activity. (A) PI3Kβ binding to DNA double strand breaks (DSBs) recruits DNA damage sensor and DNA repair enzymes. (B) PI3Kγ comprising of the p110γ and p87, catalytic and regulatory subunits, serves as scaffold for a Protein Kinase A (PKA) and phosphodiesterase 3B (PDE3B) containing protein complex that regulates β-adrenergic receptor internalization and muscle contractility in cardiomyocytes.