Figure 2

Kinase actitvity-independent functions of the EGFR/ERBBs. (A) EGFR prevents autophagic cell death by stabilizing the sodium/glucose cotransporter (SGLT1) thus maintaining the basal intracellular glucose level. (B) In glioblastomas, EGFR and EGFR vIII sequester the proapoptotic Bcl-2 family member PUMA in the cytoplasm leading to tumour drug resistance. (C) EGFR and ERBB4 regulate gene expression by direct interaction with transcription factors in the nucleus.