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Figure 1 | Cell Communication and Signaling

Figure 1

From: Phosphatases in the cellular response to DNA damage

Figure 1

A simplified view of the cellular response to DNA damage. Single and double stranded DNA breaks signal through the sensors (MRN and 9-1-1) shown in purple, mediators (H2AX, BRCA1, MDC1, 53BP1) shown in blue, signal transducing kinases (ATM, ATR) shown in yellow, effector kinases (CHK2, CHK1) shown in pink, and effector proteins (E2F1, p53, Cdc25) shown in green, leading to gene transcription, apoptosis, and cell cycle arrest. Proteins that are phosphorylated by ATM, ATR, and/or DNA-PK are marked by a yellow phosphate group and proteins that are phosphorylated by CHK2 and/or CHK1 are marked by a pink phosphate group.

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Cell Communication and Signaling

ISSN: 1478-811X