Endocytosis, cell signalling, adhesion and motility

Endocytosis and exocytosis play a key role in how cells respond to their environment. Endocytosis directly (and indirectly) affects responses to guidance cues and growth factors, the uptake of nutrients and even pathogens; it modulates cell signalling in response to receptor activation and is essential for cell migration. In this talk I will consider the endocytic repertoire of a cell and show how distinct mechanisms may differently affect function. I will describe the characterisation of new endocytic mechanisms and show how a molecular understanding can lead to a better view of function. I will round up with a simple view of how exocytosis can be regulated by calcium mediated signalling.