- Meeting abstract
- Open Access
Endocytosis, cell signalling, adhesion and motility
- HT McMahon1
© McMahon; licensee BioMed Central Ltd. 2009
- Published: 26 February 2009
- Growth Factor
- Cell Migration
- Cell Signalling
- Receptor Activation
Endocytosis and exocytosis play a key role in how cells respond to their environment. Endocytosis directly (and indirectly) affects responses to guidance cues and growth factors, the uptake of nutrients and even pathogens; it modulates cell signalling in response to receptor activation and is essential for cell migration. In this talk I will consider the endocytic repertoire of a cell and show how distinct mechanisms may differently affect function. I will describe the characterisation of new endocytic mechanisms and show how a molecular understanding can lead to a better view of function. I will round up with a simple view of how exocytosis can be regulated by calcium mediated signalling.
- Mittal R, Peak-Chew S-Y, McMahon HT: Acetylation of MEK2 and IkB kinase (IKK) activation loop residues by YopJ inhibits signalling. Proc Natl Acad Sci USA. 2006, 103: 18574-18579. 10.1073/pnas.0608995103.PubMed CentralView ArticlePubMedGoogle Scholar
- Schmid EM, McMahon HT: Integrating molecular and network biology to decode endocytosis. Nature. 2007, 448: 883-888. 10.1038/nature06031.View ArticlePubMedGoogle Scholar
- Martens S, McMahon HT: Mechanisms of membrane fusion: disparate players and common principles. Nat Rev Mol Cell Biol. 2008, 9: 543-556. 10.1038/nrm2417.View ArticlePubMedGoogle Scholar
- Daumke O, Lundmark R, Vallis Y, Martens S, Butler J, McMahon HT: Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling. Nature. 2007, 449: 923-927. 10.1038/nature06173.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd.