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Endocytosis, cell signalling, adhesion and motility

Endocytosis and exocytosis play a key role in how cells respond to their environment. Endocytosis directly (and indirectly) affects responses to guidance cues and growth factors, the uptake of nutrients and even pathogens; it modulates cell signalling in response to receptor activation and is essential for cell migration. In this talk I will consider the endocytic repertoire of a cell and show how distinct mechanisms may differently affect function. I will describe the characterisation of new endocytic mechanisms and show how a molecular understanding can lead to a better view of function. I will round up with a simple view of how exocytosis can be regulated by calcium mediated signalling.


  1. Mittal R, Peak-Chew S-Y, McMahon HT: Acetylation of MEK2 and IkB kinase (IKK) activation loop residues by YopJ inhibits signalling. Proc Natl Acad Sci USA. 2006, 103: 18574-18579. 10.1073/pnas.0608995103.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  2. Schmid EM, McMahon HT: Integrating molecular and network biology to decode endocytosis. Nature. 2007, 448: 883-888. 10.1038/nature06031.

    Article  CAS  PubMed  Google Scholar 

  3. Martens S, McMahon HT: Mechanisms of membrane fusion: disparate players and common principles. Nat Rev Mol Cell Biol. 2008, 9: 543-556. 10.1038/nrm2417.

    Article  CAS  PubMed  Google Scholar 

  4. Daumke O, Lundmark R, Vallis Y, Martens S, Butler J, McMahon HT: Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling. Nature. 2007, 449: 923-927. 10.1038/nature06173.

    Article  CAS  PubMed  Google Scholar 

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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McMahon, H. Endocytosis, cell signalling, adhesion and motility. Cell Commun Signal 7 (Suppl 1), A101 (2009).

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