Early cellular signaling responses to axonal injury

Lukas, Thomas J; Wang, Ai Ling; Yuan, Ming; Neufeld, Arthur H

doi:10.1186/1478-811X-7-5

Cell Communication and Signaling

Table 2 Selected phosphoproteins identified in the neural retina after axonal injury*.

From: Early cellular signaling responses to axonal injury

Accession Number	Protein	Direction**	Description
Calcium/Potassium channels and regulators
IPI00407939	GRIA1	Up	Glutamate receptor, ionotropic, AMPA1
IPI00467841	CALM1	Up	Calmodulin 1
IPI00118978	HCN1	Up	Hcn1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
IPI00409286	TRPM4	Down	Trpm4 Isoform 1 of Transient receptor potential cation channel subfamily M member 4
IPI00752412	ATP1A3	Down	ATPase, Na+/K+ transporting, alpha 3 polypeptide
IPI00132450	RGS10	Up	Regulator of G-protein signaling 10
IPI00122549	VDAC1	Up	Isoform1 of VDAC Voltage-dependent anion-selective channel 1
Signal Transduction
TNF-alpha pathway
IPI00126078	JAK1	Up	Tyrosine-protein kinase JAK1
IPI00122372	TTRAP	Up	TRAF and TNF receptor-associated protein
IPI00124590	CASP8AP2	Down	Casp8ap2 CASP8-associated protein 2
IPI00348883	CARD9	Down	Card9 Novel protein containing a caspase recruitment domain
IPI00108549	SDCCAG3	Down	Sdccag3 serologically defined colon cancer antigen 3 isoform 1
IPI00124414	DAB2IP	Down	Dab2 interacting protein (ASK-interacting protein1)
MAPK-ERK-1 Pathway
IPI00755254	OSBP	Up	Similar to Oxysterol-binding protein 1
IPI00111234	MAGI3	Down	Magi3 Membrane-associated guanylate kinase-related MAGI-3
IPI00171977	USP8	Up	Ubiquitin carboxy-terminal hydrolase 8
IPI00170221	ARHGEF6	Up	Rac/CDC42 exhange factor (GEF) 6
Nuclear Activity
IPI00753411	SYNE2	Up	Similar to spectrin repeat containing, nuclear envelope 2 isoform a
IPI00460716	JMJD1A	Up	Isoform 1 of JmjC domain-containing histone demethylation protein 2A
IPI00461474	SYNE1	Up	Synaptic nuclear envelope 1, full insert sequence
IPI00228557	TCF20	Up	TCF20 (transcription factor 20) – SPBP
IPI00331063	XPO4	Up	Exportin-4
IPI00751267	H2AO	Up	Similar to H2A histone family, member O
IPI00462466	SETD2	Up	SET domain containing 2-Huntington interacting protein B (Histone methyltransferase)
IPI00761953	SFRS2IP	Up	Splicing factor, serine arginine rich 2 interacting protein
IPI00750315	DCP2	Up	PREDICTED: similar to mRNA decapping enzyme 2
IPI00458583	HNRPU	Up	Heterogeneous nuclear ribonucleoprotein U
IPI00136883	PTBP1	Up	hnRNP I Heterologous nuclear ribonuclear protein I
IPI00421190	STAG2	Up	Stromal Antigen 2
IPI00119301	HES6	Up	Transcription cofactor HES6

*Listing the proteins in Table 2 was based upon the following criteria: 1) the underlying peptides were detected at least twice in the data, 2) the identified protein has known phosphorylation sites in the Phosphosite database [50], and 3) the phosphoprotein levels changed (up/down) by approximately two-fold after axonal injury.
**Direction is the up or down change in phosphopeptide level based upon the average of the 30, 60 min and 6 hrs values divided by the control value.

Back to article page

ISSN: 1478-811X

Contact us

General enquiries: journalsubmissions@springernature.com