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Table 2 Selected phosphoproteins identified in the neural retina after axonal injury*.

From: Early cellular signaling responses to axonal injury

Accession Number Protein Direction** Description
Calcium/Potassium channels and regulators
IPI00407939 GRIA1 Up Glutamate receptor, ionotropic, AMPA1
IPI00467841 CALM1 Up Calmodulin 1
IPI00118978 HCN1 Up Hcn1 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
IPI00409286 TRPM4 Down Trpm4 Isoform 1 of Transient receptor potential cation channel subfamily M member 4
IPI00752412 ATP1A3 Down ATPase, Na+/K+ transporting, alpha 3 polypeptide
IPI00132450 RGS10 Up Regulator of G-protein signaling 10
IPI00122549 VDAC1 Up Isoform1 of VDAC Voltage-dependent anion-selective channel 1
Signal Transduction    
TNF-alpha pathway    
IPI00126078 JAK1 Up Tyrosine-protein kinase JAK1
IPI00122372 TTRAP Up TRAF and TNF receptor-associated protein
IPI00124590 CASP8AP2 Down Casp8ap2 CASP8-associated protein 2
IPI00348883 CARD9 Down Card9 Novel protein containing a caspase recruitment domain
IPI00108549 SDCCAG3 Down Sdccag3 serologically defined colon cancer antigen 3 isoform 1
IPI00124414 DAB2IP Down Dab2 interacting protein (ASK-interacting protein1)
MAPK-ERK-1 Pathway    
IPI00755254 OSBP Up Similar to Oxysterol-binding protein 1
IPI00111234 MAGI3 Down Magi3 Membrane-associated guanylate kinase-related MAGI-3
IPI00171977 USP8 Up Ubiquitin carboxy-terminal hydrolase 8
IPI00170221 ARHGEF6 Up Rac/CDC42 exhange factor (GEF) 6
Nuclear Activity    
IPI00753411 SYNE2 Up Similar to spectrin repeat containing, nuclear envelope 2 isoform a
IPI00460716 JMJD1A Up Isoform 1 of JmjC domain-containing histone demethylation protein 2A
IPI00461474 SYNE1 Up Synaptic nuclear envelope 1, full insert sequence
IPI00228557 TCF20 Up TCF20 (transcription factor 20) – SPBP
IPI00331063 XPO4 Up Exportin-4
IPI00751267 H2AO Up Similar to H2A histone family, member O
IPI00462466 SETD2 Up SET domain containing 2-Huntington interacting protein B (Histone methyltransferase)
IPI00761953 SFRS2IP Up Splicing factor, serine arginine rich 2 interacting protein
IPI00750315 DCP2 Up PREDICTED: similar to mRNA decapping enzyme 2
IPI00458583 HNRPU Up Heterogeneous nuclear ribonucleoprotein U
IPI00136883 PTBP1 Up hnRNP I Heterologous nuclear ribonuclear protein I
IPI00421190 STAG2 Up Stromal Antigen 2
IPI00119301 HES6 Up Transcription cofactor HES6
  1. *Listing the proteins in Table 2 was based upon the following criteria: 1) the underlying peptides were detected at least twice in the data, 2) the identified protein has known phosphorylation sites in the Phosphosite database [50], and 3) the phosphoprotein levels changed (up/down) by approximately two-fold after axonal injury.
  2. **Direction is the up or down change in phosphopeptide level based upon the average of the 30, 60 min and 6 hrs values divided by the control value.