Figure 4From: Early cellular signaling responses to axonal injuryHistone phosphorylation and methylation. Western blots probed with A. antiphospho-H2A (Ser-139) and B. trimethyl-K4 H3 histone. Phosphorylation of H2A increased while methylation of histone H3 (at lysine-4) decreased after optic nerve injury. The demethylation of H3 persisted for several hours and started to recover at 6 hr post injury. Actin served as a loading control in these experiments.Back to article page