Figure 1
From: Expression and function of the insulin receptor substrate proteins in cancer
Schematic of the IRS protein family. Interaction domains of the IRS proteins are indicated. PH (purple), pleckstrin homology domain; PTB (purple), phosphotyrosine binding domain; KRLB (pink), kinase regulatory loop binding domain; PI3K (orange), region containing multiple PI3K binding motifs; Grb-2 (green), Grb-2 binding site; SHP-2 (yellow), SHP-2 binding site. IRS-5 and IRS-6 contain regions of similarity to each other in their C-termini (light purple).