Figure 3

RhoH in Cancer. The two major mechanisms that link RhoH to cancer are aberrant somatic hypermutation and the formation of fusion transcripts with genes such as the transcriptional repressor LAZ3/BCL6. Both mechanisms have been found in a variety of human cancers and the figure summarises the current knowledge by sorting the described cancers corresponding to their WHO classification [36]. Cancers involving somatic mutation of the RHOH gene are highlighted in blue, while cancers, where a fusion of RhoH was detected, are presented in green. Cases of leukaemia characterised by underexpression of RhoH caused by an unknown mechanism are shown in white.