Figure 3
From: Targeting focal adhesions:Helicobacter pylori-host communication in cell migration
Model of H. pylori -dependent cell elongation. Cells require a coordinated action of the actin cytoskeleton and FAs to migrate efficiently. (A) New FAs are assembled at the leading edge of motile cells, which are then disassembled after maturation at the site of retraction. (B) Motile cells infected with H. pylori become markedly elongated. This involves CagA-independent cytoskeletal rearrangements and a CagA-dependent retraction defect, which probably acts by stabilizing maturing FAs.