Figure 5

FasL proteolytic processing. Recent data suggest that FasL is processed by ADAM10 and RIPped by SPPL2a generating a free intracellular ICD. This ICD is assumed to translocate to the nucleus and to regulate gene expression, a process resembling the well characterised Notch signalling pathway. Since FasL is known to associate with SH3 domain proteins and since these interactions significantly affect FasL biology, including sorting, activation-induced release and reverse signalling, further studies have to determine how the processing of FasL affects interactions with SH3 domain proteins. Furthermore, it is unclear to date, which interactions regulate the trafficking of processed FasL fragments.