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Figure 2 | Cell Communication and Signaling

Figure 2

From: An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand

Figure 2

Inactivation of different Vav1Y3F domains reveals roles for GEF and scaffolding activities in Vav1Y3F-induced phenotypes. (A) Morphology of MCF-10A cells expressing forms of Vav1Y3F with inactivating mutations in different structural domains. Data are representative of 3 or more independent experiments. (B) Cumulative data from experiments showing migration of GFP and different forms of Vav1Y3F through transwells in the absence of EGF. GFP and Vav1Y3F were included in each experiment and migration is expressed as the percentage of migration of Vav1Y3F (set to 100%) for each individual experiment. Data are the average plus standard deviation of two (PH* and CR*) to five (SH2* and SH3*) independent experiments.

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Cell Communication and Signaling

ISSN: 1478-811X