Table 2 Kinases (human) that do not have an FXFP motif and/or D-domain sequence. Kinases that use phosphatidylinositols or inositols as substrates and do not contain an FXFP or D-domain sequence are listed in the table; all sequences are for human proteins. The number of potential MAPK phosphorylation sites and sequences fitting the optimal MAPK phosphorylation in these kinases are also identified.
Isozyme | GenBank Accession # | # amino acids | number of (S/T)P sites | Site(s) with the consensus PX(S/T)P sequence |
|---|---|---|---|---|
PI 3-kinase β | NP_006210 | 1070 | 3 | none |
PI 3-kinase, C2-β | O00750 | 1634 | 17 | none |
PIP kinase Type IIα | NP_005019 | 406 | 5 | 314PDSP |
PIP kinase Type Iiβ | P78356 | 416 | 4 | 324PDSP |
PIP kinase Type Iiγ | NP_079055 | 421 | 1 | none |
Ins(1,4,5)P3 3-kinase A | P23677 | 461 | 4 | 18PCSP 93PTSP |
Ins(1,4,5)P3 3-kinase C | NP_079470 | 683 | 8 | 334PETP |
Ins(1,3,4)P3 5/6-kinase/Ins(3,4,5,6)P4 1-kinase | NP_055031 | 414 | 3 | none |
Inositol polyphosphate multikinase/Ins(1,3,4,6)P4 5-kinase | Q8NFU5 | 416 | 5 | none |