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Figure 5 | Cell Communication and Signaling

Figure 5

From: Xenopus frizzled-4S, a splicing variant of Xfz4 is a context-dependent activator and inhibitor of Wnt/β-catenin signaling

Figure 5

Model for the modulation of Wnt/β-catenin pathway by extracellular domains of Frizzled receptors. We propose that a complex formed between Xfz4S and Wnt-3a/-8/-8b could be recognized by LRP and Wnt signaling could be activated in LRP dependent manner. Complexes between Xfz4S and Wnt-4/-5a/-11 would not be recognized by LRP and Xfz4S and Wnt/β-catenin signaling would not be activated by these Wnts.

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Cell Communication and Signaling

ISSN: 1478-811X