Skip to main content

Table 2 Effect of rottlerin and of Ro 32-0432 on PMA-dependent inhibition of the [Ca++]i rise induced by TTN. Data are expressed as percentage of the effect of TTN alone, and are shown as the mean ± SD of at least 3 separate experiments. * = P < 0.05, ** = P < 0.01 vs TTN alone; # = P < 0.01 vs TTN + PMA.

From: Intracellular calcium changes induced by the endozepine triakontatetraneuropeptide in human polymorphonuclear leukocytes: role of protein kinase C and effect of calcium channel blockers

TTN 100 μM 100.0 ± 15.5
TTN 100 μM + PMA 1 ng/ml 29.3 ± 15.5**
TTN 100 μM + PMA 1 ng/ml  
+ rottlerin 3 μM 25.0 ± 18.3**
+ rottlerin 5 μM 47.4 ± 15.1*
+ rottlerin 10 μM 61.5 ± 14.2*
TTN 100 μM + PMA 1 ng/ml  
+ Ro 32-0432 5 nM 60.0 ± 13.2**
+ Ro 32-0432 20 nM 89.5 ± 14.7#
+ Ro 32-0432 50 nM 102.3 ± 15.1#