Table 2 Effect of rottlerin and of Ro 32-0432 on PMA-dependent inhibition of the [Ca++]i rise induced by TTN. Data are expressed as percentage of the effect of TTN alone, and are shown as the mean ± SD of at least 3 separate experiments. * = P < 0.05, ** = P < 0.01 vs TTN alone; # = P < 0.01 vs TTN + PMA.
TTN 100 μM | 100.0 ± 15.5 |
TTN 100 μM + PMA 1 ng/ml | 29.3 ± 15.5** |
TTN 100 μM + PMA 1 ng/ml | |
+ rottlerin 3 μM | 25.0 ± 18.3** |
+ rottlerin 5 μM | 47.4 ± 15.1* |
+ rottlerin 10 μM | 61.5 ± 14.2* |
TTN 100 μM + PMA 1 ng/ml | |
+ Ro 32-0432 5 nM | 60.0 ± 13.2** |
+ Ro 32-0432 20 nM | 89.5 ± 14.7# |
+ Ro 32-0432 50 nM | 102.3 ± 15.1# |