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Figure 5 | Cell Communication and Signaling

Figure 5

From: Intracellular calcium changes induced by the endozepine triakontatetraneuropeptide in human polymorphonuclear leukocytes: role of protein kinase C and effect of calcium channel blockers

Figure 5

Schematic representation summarizing the putative signaling pathways acted upon by TTN in human PMNs. TTN likely activates G protein-coupled membrane receptors, which in turn signal to PLC- and PKC-dependent pathways. PKC may exert both positive and negative modulation of TTN signaling, eventually depending on the specific isoform involved. Increased [Ca++]i then occurs through both Ca++ release from intracellular stores and Ca++ entry, possibly through T-type Ca++ channels. The picture is based upon the results of the present as well as of previous studies [8,9].

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Cell Communication and Signaling

ISSN: 1478-811X