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Figure 6 | Cell Communication and Signaling

Figure 6

From: Cyclosporin A differentially inhibits multiple steps in VEGF induced angiogenesis in human microvascular endothelial cells through altered intracellular signaling

Figure 6

HIMEC growth across a leading edge demonstrated that VEGF (10 ng/ml) (■) resulted in increased monolayer expansion compared to cells which were unstimluated (). CsA (0.1 μM) treated monolayers completely blocked the effect of VEGF, and grew at rates similar to untreated cells (). The most potent inhibitor of monolayer expansion was the p44/42 MAPK inhibitor PD098059 (▲), whereas p38 MAPK inhibitor SB203580 had no effect on HIMEC monolayer expansion (□).

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