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Figure 6 | Cell Communication and Signaling

Figure 6

From: Cyclosporin A differentially inhibits multiple steps in VEGF induced angiogenesis in human microvascular endothelial cells through altered intracellular signaling

Figure 6

HIMEC growth across a leading edge demonstrated that VEGF (10 ng/ml) (■) resulted in increased monolayer expansion compared to cells which were unstimluated (◆). CsA (0.1 μM) treated monolayers completely blocked the effect of VEGF, and grew at rates similar to untreated cells (●). The most potent inhibitor of monolayer expansion was the p44/42 MAPK inhibitor PD098059 (▲), whereas p38 MAPK inhibitor SB203580 had no effect on HIMEC monolayer expansion (□).

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Cell Communication and Signaling

ISSN: 1478-811X