Figure 8
From: The Dictyostelium discoideum RACK1 orthologue has roles in growth and development
Model for DdRACK1 involvement in growth and development. The activation of Gβγ at the membrane initiates a series of events which modulates the production of PI (4,5) P2 and PI (3, 4, 5) P3 leading to the binding and recruitment of DdRACK1 (RI). DdRACK1 binds to G proteins (which may be in their free or heterotrimeric state). This association could regulate G protein interaction with downstream effectors. Phosphorylation/dephosphorylation of DdRACK1 further could regulate its cellular functions. Interaction with the different partners confers DdRACK1 with roles in various cellular processes like growth, motility and development.