Table 3 miR-125b associated with oncogenic and tumor suppressive signaling in cancer
From: Good guy or bad guy: the opposing roles of microRNA 125b in cancer
Tumor type | Direction of misregulation | miR-125b targets | Comments | Ref. |
|---|---|---|---|---|
Brain tumors | Up in ATRA differentiated glioblastoma cell lines | Bmf | Regulator of apoptosis | [31] |
| Â | Up | Connexin43 | Anti-apoptotic, pro-proliferative | [65] |
| Â | Up in neuroblastoma cells | p53 | Regulator of apoptosis | [32] |
| Â | Down | MAZ | Regulator of angiogenesis | [18] |
| Â | Down in glioma stem cells | CDK6 and CDC25A | Regulator of stem cell proliferation | [66] |
Prostate cancer | Up in androgen-independent prostate cancer | Bak1 | Pro-proliferative | [67] |
| Â | Up | p14ARF | Pro-proliferative, anti-apoptotic | [68] |
| Â | Down in androgen-treated prostate cancer cells | IGF1R | Anti-proliferative | [69] |
| Â | Down | NA | Translational control | [70] |