Figure 1

“The bad guy”: miR-125b associated with oncogenic signaling in cancer. t (2;11) (p21, q23) translocations, miR-125b-1 insertions and androgen signaling have been shown to cause an upregulation of miR-125b. This blocks the translation of target mRNAs which might promote the formation of the indicated tumor types. See also Table 1. *Upregulation of miR-125b in brain tumors and prostate cancer is controversially discussed, see main text.