Figure 4

Regulation of cerulein-induced NF-κB inflammatory response by TCPTP. Total pancreas lysates from control without (n = 9) and with (n = 12) cerulein, and panc-TCPTP KO without (n = 7) and with (n = 9) cerulein were immunoblotted for pIKKα, pIκBα, pNF-κB and their respective unphosphorylated proteins, NF-κB1 p50, and Tubulin as a loading control. Bar graphs represent normalized data for pIKKα/IKKα, pIκBα/IκBα, pNF-κB/NF-κB and NF-κB1 p50/Tubulin as means ± SEM. (**: P ≤ 0.01) indicates significant difference between saline- and cerulein-injected mice, and (#: P ≤ 0.05; ##: P ≤ 0.01) indicates significant difference between WT and KO mice.