Figure 3

Pancreatic TCPTP deficiency regulates cerulein-induced STAT3 and MAPKs signaling. Total pancreas lysates from control without (n = 9) and with (n = 12) cerulein and panc-TCPTP KO without (n = 7) and with (n = 9) cerulein were immunoblotted for pSTAT3, pERK1/2, pp38, pJNK1/2 and their respective unphosphorylated proteins, and Tubulin as a loading control. Bar graphs represent normalized data for pSTAT3/STAT3, pERK/ERK, pp38/p38, and pJNK/JNK, and presented as means ± SEM. (**: P ≤ 0.01) indicates significant difference between saline- and cerulein-injected mice, and (#: P ≤ 0.05; ##: P ≤ 0.01) indicates significant difference between WT and KO mice.