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Table 1 Pathway activation by growth factors requires Ga proteins

From: Giα proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells

EGF, HB- EGF, PDGF (low doses)

Insulin, IGF

aFGF, bFGF

PDGF (high doses)

Akt-mTORC1 pathway

+

-

+

-

ERK pathway

+

+

-

-

  1. +Giα proteins are required; - Giα proteins are not required.
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Cell Communication and Signaling

ISSN: 1478-811X