Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Figure 2 | Cell Communication and Signaling

Figure 2

From: Targeting the PDGF signaling pathway in tumor treatment

Figure 2

Mutation of PDGF receptors in malignancies. PDGFRα (left part) has been found to be activated by point mutations in about 5% of GIST cases. In the figure a mutation is indicated (star) in the juxtamembrane domain, but can occur also in other parts of the protein. In HES the intracellular part of PDGFRα (red) has been found to be fused to FIP1L1 (green), and in CMML the intracellular part of PDGFRβ (blue) has been found to be fused to TEL (yellow). Other fusion partners have also been identified.

Back to article page