Figure 7

Visualization of the weighting function used in our validation approach. Using the weighting function promotes gene sets proximal or coinciding with target genes. A weight is assigned to a gene based on its distance to the small molecules and the size of the neighborhood of the small molecule. In this toy example, we have network nodes of distance 0 (targets), 1, 2 and 3 to the small molecules targets and n _i represents the number of genes of distance i or less to these targets. The weight of a pathway gene (colored in yellow) is calculated based on the weighting function and e.g. for a node of distance 2 in this toy example, the weight is 0.860.