Figure 9
From: The effects of CA IX catalysis products within tumor microenvironment
Silencing of CA IX in fibroblasts decreases tumor growth rate. Xenograft growth in SCID bg/bg mice of wild-type (control) or CA IX-silenced CAFs injected s.c. with PC3 cells (CAFs:PC3 cells ratio 1:5). CA IX silencing by RNA interference in fibroblasts is shown (Timepoint 14 days: ***, p < 0.01; timepoint 16 days: ****, p < 0.005). Linear regression equation of 'CAFs + PC3′’: y = 0.08065 (± 0.01035) x – 0.82478 (± 0.14473), R2 = 0.9676; linear regression equation of 'CAFs CA IX sil + PC3′: y = 0.023219 (± 0.003469) x – 0.249096 (± 0.051038), R2 = 0.9563.