Figure 4
From: A rapid and sensitive assay of intercellular coupling by voltage imaging of gap junction networks
Data fit by a simple resistive network model that reflects the anatomy. The inset shows model scheme. Simulations were performed using the ngspice software (http://ngspice.sourceforge.net). N x = 45 and N y = 15 indicate the number of rows and columns in the grid, respectively. Each node represents one cell and each link represents a resistive connection between adjacent nodes. The patch pipette connected to cell 1 was simulated as a variable voltage source connected to one node of the grid through an access resistance R a = 7.8 MΩ (not shown). A single value for membrane conductance (g m = 8.3 nS) and junctional conductance (g j ) were used throughout the network. g j was left as the only free parameter in the simulations and its value was derived using a maximum–likelihood algorithm.