Figure 7
From: Zinc inhibits osteoclast differentiation by suppression of Ca2+-Calcineurin-NFATc1 signaling pathway
The proposed molecular mechanism for the inhibitory effects of zinc on RANKL-induced osteoclastogenesis. Schematic models of the inhibitory effects of zinc on the Ca2+-Calcineurin-NFATc1 signaling pathway; (A) Zinc may inhibit calcineurin in the cytosol in the early period of osteoclastogenesis. (B) In the middle or late period, zinc could be suppressing calcium oscillations by blocking calcium influx from extracellular space. Cn A, Calcineurin A subunit; CaM, Calmodulin; P, phosphorylated.