Figure 3

Src is a critical mediator for caveolin-1 induction. (A) SU6656 (SU; 15 μM) was used to block Src activity. Blockage yielded in reduced caveolin-1 protein (evaluated with densitometry) similar to (B) where PP2 (10 μM) was used. (C, D) Caveolin-1 mRNA expression is also reduced during culture in presence of inhibitors (p = 0.002 for SU6656 at d4; p < 0.001 for PP2 at d4). (E, F) Induction of Collagen 1α1 was reduced upon Src inhibition with both inhibitors (SU6656: p < 0.001; PP2: p = 0.005).