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Table 1 Metabolic phenotyping of control and DEP-1 ASO treated mice

From: Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice

  Control ASO DEP-1 ASO P-value
LabMaster analysis    
Food intake [g] 1.7 ± 0.2 2.0 ± 0.1 0.230
Water intake [ml] 1.8 ± 0.2 2.1 ± 0.2 0.317
Temperature [°C] 20.379 ± 0.015 20.520 ± 0.018 < 0.001
Locomotor activity [x + y] 61426 ± 5246 53600 ± 4465 0.287
Locomotor activity [z] 6296 ± 1095 4678 ± 770 0.217
Organ weight    
[organ weight mg/body weight g]
Epididymal fat 18.4 ± 1.7 13.8 ± 1.0 0.038
Perirenal fat 7.3 ± 0.8 5.1 ± 0.6 0.048
Liver 38.6 ± 1.7 51.8 ± 0.9 < 0.001
Heart 4.8 ± 0.3 4.3 ± 0.1 0.197
Kidney 11.3 ± 0.9 11.1 ± 0.5 0.830
  1. Control ASO and DEP-1 ASO mice were characterized using metabolic cages (LabMaster) 4 weeks after ASO treatment. Measurements of an 18 hours period (12 am–6 am) are shown. Data were recorded every 15 min. After sacrificing of mice, organs weights were determined. Data are shown as mean ± standard error of the mean.