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Table 1 Summary of the results obtained from the MASER-12 suborbital space flight mission

From: Signal transduction in primary human T lymphocytes in altered gravity – results of the MASER-12 suborbital space flight mission

  Target molecule
  CD3 IL-2R ZAP-70 LAT (pY171) LAT (pY226) P-p44/42 MAPK p- tyrosine Acetyl-histone H3 Vimentin β-tubulin
Effect of cultivation in experiment hardware H/W compared to CC ↓** - ↓** ↓** ↑** - - ↑** ↓** -
Effect of launch phase / hypergravity BL compared to H/W ↓** ↓** ↓* - ↑* ** ↓** ↓** ↓** -
Effect of microgravity non-activated T cells (μg and 1g compared to H/W) ↓** ↓** - - - ↓* - - - -
Effect of microgravity non-activated T cells (direct comparison μg vs. 1g) - - - - - ↓* - - - -
Effect of microgravity ConA/CD28-activated T cells (μg and 1g compared to BL) ↓* ↓* - - - - - - - ↑**
Effect of microgravity ConA/CD28-activated T cells (direct comparison μg vs. 1g) - - - - - - - - - -
  1. The effect of cultivation in experiment hardware (H/W compared to CC), the effect of launch phase / hypergravity (BL compared to H/W), the effect of microgravity in non-activated T cells (μg and 1g compared to BL and direct comparison μg vs. 1g) and the effect of microgravity in ConA/CD28-activated T cells (μg and 1g compared to BL and direct comparison μg vs. 1g) are demonstrated. (↑*): increase, p<0.1; (↑**): increase, p<0.05 according to two-tailed Mann–Whitney-U-Test. (↓*): decrease, p<0.1, (↓**): decrease, p<0.05 according to two-tailed Mann–Whitney-U-Test. ( ): no significant changes.