Signal transduction in primary human T lymphocytes in altered gravity – results of the MASER-12 suborbital space flight mission

Table 1 Summary of the results obtained from the MASER-12 suborbital space flight mission

	Target molecule
	CD3	IL-2R	ZAP-70	LAT (pY171)	LAT (pY226)	P-p44/42 MAPK	p- tyrosine	Acetyl-histone H3	Vimentin	β-tubulin
Effect of cultivation in experiment hardware H/W compared to CC	↓**	-	↓**	↓**	↑**	-	-	↑**	↓**	-
Effect of launch phase / hypergravity BL compared to H/W	↓**	↓**	↓*	-	↑*	↓**	↓**	↓**	↓**	-
Effect of microgravity non-activated T cells (μg and 1g compared to H/W)	↓**	↓**	-	-	-	↓*	-	-	-	-
Effect of microgravity non-activated T cells (direct comparison μg vs. 1g)	-	-	-	-	-	↓*	-	-	-	-
Effect of microgravity ConA/CD28-activated T cells (μg and 1g compared to BL)	↓*	↓*	-	-	-	-	-	-	-	↑**
Effect of microgravity ConA/CD28-activated T cells (direct comparison μg vs. 1g)	-	-	-	-	-	-	-	-	-	-

The effect of cultivation in experiment hardware (H/W compared to CC), the effect of launch phase / hypergravity (BL compared to H/W), the effect of microgravity in non-activated T cells (μg and 1g compared to BL and direct comparison μg vs. 1g) and the effect of microgravity in ConA/CD28-activated T cells (μg and 1g compared to BL and direct comparison μg vs. 1g) are demonstrated. (↑*): increase, p<0.1; (↑**): increase, p<0.05 according to two-tailed Mann–Whitney-U-Test. (↓*): decrease, p<0.1, (↓**): decrease, p<0.05 according to two-tailed Mann–Whitney-U-Test. ( ): no significant changes.

ISSN: 1478-811X