Target molecule | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
CD3 | IL-2R | ZAP-70 | LAT (pY171) | LAT (pY226) | P-p44/42 MAPK | p- tyrosine | Acetyl-histone H3 | Vimentin | β-tubulin | |
Effect of cultivation in experiment hardware H/W compared to CC | ↓** | - | ↓** | ↓** | ↑** | - | - | ↑** | ↓** | - |
Effect of launch phase / hypergravity BL compared to H/W | ↓** | ↓** | ↓* | - | ↑* | ↓** | ↓** | ↓** | ↓** | - |
Effect of microgravity non-activated T cells (μg and 1g compared to H/W) | ↓** | ↓** | - | - | - | ↓* | - | - | - | - |
Effect of microgravity non-activated T cells (direct comparison μg vs. 1g) | - | - | - | - | - | ↓* | - | - | - | - |
Effect of microgravity ConA/CD28-activated T cells (μg and 1g compared to BL) | ↓* | ↓* | - | - | - | - | - | - | - | ↑** |
Effect of microgravity ConA/CD28-activated T cells (direct comparison μg vs. 1g) | - | - | - | - | - | - | - | - | - | - |