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Hepatic autophagy is differentially regulated in periportal and pericentral zones - a general mechanism relevant for other tissues?
Wnt signal pathway and zonation of the liver lobules
Go Yoshida, Tokyo Medical and Dental University
11 September 2015
It has recently been reported that Axin2-positive hepatic stem cells near to the central vein strongly express glutamine synthase. In contrast, periportal hepatic cells have been shown to express carbamoyl-phosphate synthase 1. The endothelial cells of the central vein secrete Wnt ligands, therefore central vein corresponds to the niche for hepatic stem cells with enhanced level of canonical Wnt signal. The gradient difference in this signaling pathway is considered to be responsible for the zonation of liver cell architecture in coordination with the gradient oxygen concentration.
Ref; Wang B, Zhao L, Fish M, Logan CY, Nusse R. Self-renewing diploid Axin2 cells fuel homeostatic renewal of the liver. Nature. 2015 Aug 13;524(7564):180-5.
Cell Communication and Signaling
Wnt signal pathway and zonation of the liver lobules
11 September 2015
It has recently been reported that Axin2-positive hepatic stem cells near to the central vein strongly express glutamine synthase. In contrast, periportal hepatic cells have been shown to express carbamoyl-phosphate synthase 1. The endothelial cells of the central vein secrete Wnt ligands, therefore central vein corresponds to the niche for hepatic stem cells with enhanced level of canonical Wnt signal. The gradient difference in this signaling pathway is considered to be responsible for the zonation of liver cell architecture in coordination with the gradient oxygen concentration.
Ref; Wang B, Zhao L, Fish M, Logan CY, Nusse R. Self-renewing diploid Axin2 cells fuel homeostatic renewal of the liver. Nature. 2015 Aug 13;524(7564):180-5.
Competing interests
There are no competing interests to be addressed.