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Table 1 Internalization of IGF-II and insulin through IR-B by microscopy

From: Insulin and insulin like growth factor II endocytosis and signaling via insulin receptor B

Time at 37°C 0 min 10 min 20 min 150 min
Ligand Insulin IGF-II Insulin IGF-II Insulin IGF-II Insulin IGF-II
Average 0.06 0.17 0.38 0.60 0.41 0.72 0.95 0.96
s.e.m 0.01 0.03 0.03 0.03 0.03 0.03 0.01 0.01
n 28 29 10 20 20 20 23 19
p (insulin versus IGF-II) 2E-03 9E-06 7E-09 9E-01
  1. Quantification of the degree of internalization of IGF-II and insulin in HeLa cells expressing IR-B-SYFP labeled in vivo with 50 nM BAC-Ins and 1 nM QD655 at room temperature.