Figure 2

Gene expression analysis of the NK cell activation, DC maturation and host cell antimicrobial defense networks. Intensity plot and network analysis was derived from the SDEG altered by Mtb infection compared to the uninfected reference at 2, 4, 8 and 12 weeks post-infection using Partek Genomics Suite (PGS) and Ingenuity Pathway Analysis (IPA) software. Intensity plot (A) and interaction map (D) of NK cell activation network. Intensity plot (B) and interaction map (E) of DC maturation network. Intensity plot (C) and interaction map (F) of host cell antimicrobial defense network. The scale for all intensity plots ranges from +4 (red) to -4 (blue). Red symbols in the networks indicate up-regulation; green denotes down-regulation of gene expression. For D, E and F, the gradation in the color intensity of gene symbols is proportional to their relative expression level at 2 weeks post-infection.