Figure 10
From: Invasion of epithelial cells by Campylobacter jejuni is independent of caveolae
Comprehensive model of C. jejuni internalization. The activation of the EGF receptor and FAK, which results following C. jejuni infection via the activation of the α5β1 integrins, induces c-Src activity and the phosphorylation of caveolin-1. Uptake of C. jejuni requires the recruitment of key components of the focal complex (i.e., FAK, paxillin, vinculin, p130Cas, the CrkII/DOCK-180/ELMO complex). Focal complex assembly promotes the activation of Erk 1/2, Rac1, Cdc42, cortactin, and N-WASP leading to actin cytoskeletal reorganization.