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Figure 6 | Cell Communication and Signaling

Figure 6

From: Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts

Figure 6

Proposed hypothetical model describing different p38 signalling pathways in response to mitogens and cellular stress. Anisomycin leads to a sustained phosphorylation of p38 which is independent of upstream-acting small GTPases and accompanied by an accumulation of p38 in the nucleus. One downstream substrate of p38 is CREB. In contrast, p38 is transiently phosphorylated after serum-stimulation in a GTPase-dependent manner and cyclin D1 is upregulated. The cellular response is proliferation.

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