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Figure 8 | Cell Communication and Signaling

Figure 8

From: Role of TLR4/NADPH oxidase/ROS-activated p38 MAPK in VCAM-1 expression induced by lipopolysaccharide in human renal mesangial cells

Figure 8

Schematic representation of the signaling pathways involved in the LPS-induced inflammatory responses. LPS induced ROS production through TLR4/MyD88/c-Src/NADPH oxidase, in turn initiates the activation of p38 MAPK and ATF2. Activated ATF2 was recruited to the promoter region of VCAM-1 leading to an increase of VCAM-1 promoter activity and the expression of VCAM-1. Up-regulation of VCAM-1 enhances the adhesion of THP-1 ells to HRMCs challenged with LPS.

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Cell Communication and Signaling

ISSN: 1478-811X