Skip to main content
Figure 4 | Cell Communication and Signaling

Figure 4

From: In vitro silencing of the insulin receptor attenuates cellular accumulation of fibronectin in renal mesangial cells

Figure 4

InsR silencing induced reduction in cellular accumulation of FN was partially dependent on PI3K/Akt. Cells were transfected with SC, sh-InsR, sh-InsR + dominant negative Akt (DN-Akt) cDNA or sh-InsR + activated H-Ras (aH-Ras) cDNA. Cell lysates were subject to Western blotting with an anti-FN antibody. A gel stained after transfer was shown as a loading monitor. The bar graph shows the densitometric scanning result (means ± SEM) from four independent experiments. *, P<0.01, NS, no significant difference.

Back to article page

Cell Communication and Signaling

ISSN: 1478-811X