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Table 1 Ontology analysis of the differentially expressed macrophage genes by Mtb infection

From: Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophages

Biological function Number of differentially expressed genes
  6 hours 24 hours
  CDC1551 HN878 CDC1551 HN878
Inflammatory response 391 343 221 232
Cellular growth and proliferation 650 549 325 371
Cell-to-cell signaling and interaction 334 305 217 224
Antigen presentation 147 150 115 117
Cell death 512 455 243 279
Cell cycle 333 279 157 186
DNA replication, recombination and repair 212 141 54 69
Gene expression 507 399 161 178
Small molecule biochemistry 257 221 112 173
Lipid metabolism 211 188 112 150
  1. Total host RNA was isolated from the BMM infected with Mtb CDC1551 or HN878 at 6 and 24 hpi and analyzed by microarray. The list of differentially expressed genes (at least 2 fold changes in expression levels and P ≤ 0.05) was uploaded into IPA software for functional analysis. The number of significantly differentially expressed host genes upon Mtb infection at 6 and 24 hpi and their respective biological function are shown.