Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophages

Table 1 Ontology analysis of the differentially expressed macrophage genes by Mtb infection

Biological function	Number of differentially expressed genes
	6 hours		24 hours
	CDC1551	HN878	CDC1551	HN878
Inflammatory response	391	343	221	232
Cellular growth and proliferation	650	549	325	371
Cell-to-cell signaling and interaction	334	305	217	224
Antigen presentation	147	150	115	117
Cell death	512	455	243	279
Cell cycle	333	279	157	186
DNA replication, recombination and repair	212	141	54	69
Gene expression	507	399	161	178
Small molecule biochemistry	257	221	112	173
Lipid metabolism	211	188	112	150

Total host RNA was isolated from the BMM infected with Mtb CDC1551 or HN878 at 6 and 24 hpi and analyzed by microarray. The list of differentially expressed genes (at least 2 fold changes in expression levels and P ≤ 0.05) was uploaded into IPA software for functional analysis. The number of significantly differentially expressed host genes upon Mtb infection at 6 and 24 hpi and their respective biological function are shown.

ISSN: 1478-811X