Figure 4

The merged TCR and IL-2R signaling network. The top layer represents input nodes and the bottom layer outputs, i.e. molecules including transcription factors that become activated. Solid black arrows indicate activating interactions with black circles denoting AND-connections. For clarity, activating influences with arrows pointing from the bottom to the top are drawn with dashed black lines. Red lines mark inhibitory interactions that are expressed as NOT-conditions in the logical network. Nodes specific to the IL-2R and TCR network are shown in blue and green, respectively. Common nodes are depicted in red. The insert shows a magnified region of the network. Further details can be found in[38].