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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Signaling controversy and future therapeutical perspectives of targeting sphingolipid network in cancer immune editing and resistance to tumor necrosis factor-α immunotherapy

Fig. 7

The conceptual model for the regulation of immune T cell responses by the SphK/S1P/S1PR axis during cancer progression. Sphingolipids were shown to impact cancer cell recognition and killing by immune cells at different levels. Abbreviations: PD-1, programmed death-1; PD-L1, programmed death-1 (PD-1) ligand 1; ROS, reactive oxygen species; S1P, sphingosine-1-phosphate; S1P1/S1P3, sphingosine-1-phosphate receptor 1 and 3; SphK, sphingosine kinase; WNT, wingless-related integration site

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Cell Communication and Signaling

ISSN: 1478-811X