Fig. 3From: Endothelial cell dynamics in sepsis-induced acute lung injury and acute respiratory distress syndrome: pathogenesis and therapeutic implicationsOxidative stress response in ECs. Reactive oxygen species (ROS) within ECs primarily originate from mitochondria, NADPH oxidases (NOXs), endothelial nitric oxide synthase (eNOS) uncoupling, and xanthine oxidase (XO). The generation of ROS through various pathways results in the upregulation of ROS expression in ECs, leading to mechanical cell death and disruption of intercellular junctionsBack to article page